Depressants are psychoactive drugs that temporarily diminish the normal function of the brain and central nervous system. Depressant reduces the stimulation. These drugs include opiates and opioids, barbiturates, benzodiazepines, tranquilizers and alcohol. Due to their effects, these drugs can be referred to as “downers”. They can leave a severe impact on concentration and coordination. Small dose can give you a more relaxed feeling. Large doses cause drowsiness, vomits and unconsciousness.
Types of Depressants
Alcohol is the most frequently used depressant. Types of alcohol include beer, wine, and liquor. Alcohol is a psychoactive drug that reduces attention and slows reaction speed. Alcohol intoxication affects the brain, causing slurred speech, clumsiness, and delayed reflexes. Other physiological effects include altered perception of space and time, reduced psychomotor skills, disrupting equilibrium. The immediate effects of a large amount of alcohol include slurred speech, disturbed sleep, nausea, and vomiting. Even at low doses, alcohol significantly impairs judgment and coordination.
Long Term Effects of Alcohol
Regular use of alcohol would give following long term effects:
- Poor memory and brain damage
- Difficulty in having pregnancy
- Liver disease
- High blood pressure
- Heart disease
Barbiturates are a group of drugs known as sedative-hypnotics, creating sleep-inducing and anxiety-decreasing effects. Barbiturates produce effects from mild sedation to total anesthesia. Barbiturates can be injected into veins or muscles, but usually taken in pill form. They are sedatives used to treat insomnia, anxiety, and seizures. Barbiturates produce similar effects during intoxication.
Symptoms of Barbiturate Intoxication
- Respiratory depression
- Low blood pressure
- Unusual excitement
- Poor concentration
- Impaired coordination
- Impaired judgment
- Respiratory arrest which may lead to death
Users report that a barbiturate high gives feelings of relaxed contentment and euphoria. The main risk of abuse is respiratory depression. Other effects of barbiturate intoxication include drowsiness, lateral and vertical nystagmus, slurred speech and ataxia, decreased anxiety and loss of inhibitions.
Benzodiazepine, commonly referred to as “benzo”, are most commonly used to treat insomnia and anxiety. The five most common benzos are Xanax, Ativan, Klonopin, Valium, and Restoril. Benzodiazepines are used to produce sedation, induce sleep, relieve anxiety and muscle spasms, and to prevent seizures. In general, they act as hypnotics in high doses, anxiolytics in moderate doses, and sedatives in low doses.
Effects of Benzodiazepine
It has different effects on everyone which are mentioned below
- Drowsiness and fatigue
- Dry mouth
- Slurred speech
- Blurred vision
- Nausea and loss of appetite
Opiates are found in opium. The major active opiates found in opium are morphine, codeine, thebaine, and papaverine. Semi-synthetic opioid such as heroin, oxycodone, and hydrocodone are derived from these substances as well. Opiates can be injected, snorted, or smoked. The short-term effect of opiate abuse consists of a surge of euphoria coupled with a warm flushing of the skin, dry mouth, and heavy extremities. Following initial euphoria, users alternate between a wakeful and drowsy state. Mental functioning becomes clouded due to the depression of the central nervous system.
Tranquilizers are used to treat anxiety or problems with sleep. They have a calming effect by depressing the nervous system in a way similar to alcohol. They are the most commonly prescribed psychiatric medications. Tranquilizers produce a relaxing and anxiety-reducing effect.
- Minor tranquilizers have direct depressant effects on brain areas that regulate wakefulness and alertness. They enhance the action of receptors that stimulate the nervous system.
- Major tranquilizers primarily affect specific receptors in the brain that reduce psychotic thoughts, perceptions and agitation.
General side effects may include:
- Cognitive/Memory Impairment
- Muscle relaxation
- Lowered blood pressure/heart rate
- Respiratory depression
- Anticonvulsant effects
- Feelings of euphoria
Most CNS depressants act on the brain by affecting the neurotransmitter gammaaminobutyric acid (GABA). Neurotransmitters are brain chemicals that enable communication between brain cells. GABA works by decreasing brain activity. So, due to depressants ability to increase GABA activity, a drowsy or calming effect is produced.
With continued use of depressants, the body will develop a tolerance for the drugs, requiring larger doses to achieve the initial effects. When use is reduced or stopped, the withdrawal will occur due to the reuse of brain activity, potentially leading to seizures and other harmful consequences.